Background: Idiopathic pulmonary fibrosis (IPF) is an incurable, debilitating disease which impairs lung function and eventually leads to death. Currently, there is a lack of effective modifying therapies and treatments for IPF as the underlying epidemiological mechanism is not clearly understood. This leads to difficulty in diagnosing and managing IPF, which results in a high incurment of disease-associated cost.
View Article and Find Full Text PDFJ Intensive Care Soc
November 2015
We report a case of a 75-year-old patient who presented with severe acute kidney injury due to Goodpasture's syndrome. It is an uncommon autoimmune condition, requiring treatment with immunosuppressive drugs and plasma exchange. Prognosis depends largely on early diagnosis, so it is important to be aware of these rarer causes whenever anyone presents with acute kidney injury.
View Article and Find Full Text PDFObjectives: To determine the comparative effectiveness and cost-effectiveness of conventional ventilatory support versus extracorporeal membrane oxygenation (ECMO) for severe adult respiratory failure.
Design: A multicentre, randomised controlled trial with two arms.
Setting: The ECMO centre at Glenfield Hospital, Leicester, and approved conventional treatment centres and referring hospitals throughout the UK.