Publications by authors named "C Hermida-Merino"
Article Synopsis
- - Gelatin is a widely used biopolymer in medicine because it's safe and doesn't trigger inflammation, and it can form Ionogels with ionic liquids (ILs) as cosolvents for better drug delivery.
- - The study focuses on using a specific IL, 1-ethyl-3-methylpyridinium perfluorobutanesulfonate (FIL), with fish gelatin to enhance the solubility of drugs like Doxorubicin while maintaining the mechanical and nanostructural properties of the material.
- - Controlled release mechanisms of Doxorubicin and Mithramycin from different Ionogel formulations were compared to traditional gelatin hydrogels, highlighting the importance of structural design for
A series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles featuring different nanostructures were designed to generate multifunctional drug delivery systems with tailored release rates required for personalized treatment approaches. The global conception of the systems was considered from the desired customization of the drug release while featuring the viscoelastic properties needed for their ease of storage and posterior local administration as well as their biocompatibility and cell growth capability for the successful administration at the biomolecular level. The hydrogel matrix offers the support to develop a direct thermal method to convert the typical kinetic trapped nanostructures afforded by the formulation method whilst avoiding the detrimental nanoparticle agglomeration that diminishes their therapeutic effect.
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- Yellowfin tuna skin, rich in collagen, presents a valuable opportunity for innovation in the fishery industry by being transformed into gelatin and hydrogels ideal for drug delivery.
- The study developed novel tuna gelatin hydrogels to deliver antitumoral drugs Doxorubicin and Crocin locally after surgery, showing favorable mechanical properties and drug release profiles.
- Various analytical techniques confirmed the structural composition and effectiveness of the gelatin hydrogels, revealing their ability to improve sustained release of the drugs, highlighting the significance of their structure in therapeutic applications.
The expansion of fish filleting, driven by the increasing demand for convenience food, concomitantly generates a rising amount of skinning by-products. Current trends point to a growing share of aquaculture in fish production, so we have chosen three established aquaculture species to study the properties of gelatin extracted from their skin: rainbow trout, commonly filleted; and seabass and seabream, marketed whole until very recently. In the first case, trout skin yields only 1.
View Article and Find Full Text PDFRising trends in fish filleting are increasing the amount of processing by-products, such as skins of turbot, a flatfish of high commercial value. In line with circular economy principles, we propose the valorization of turbot skins through a two-step process: initial gelatin extraction described for the first time in turbot, followed by hydrolysis of the remaining solids to produce collagen hydrolysates. We assayed several methods for gelatin extraction, finding differences in gelatin properties depending on chemical treatment and temperature.
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