Publications by authors named "C Hering"
While moderately activated microglia in Alzheimer's disease (AD) are pivotal in clearing amyloid beta (Aβ), hyperactivated microglia perpetuate neuroinflammation. Prior investigations reported that the elimination of ~80% of microglia through inhibition of the colony-stimulating factor 1 receptor (CSF1R) during the advanced stage of neuroinflammation in 5xFamilial AD (5xFAD) mice mitigates synapse loss and neurodegeneration. Furthermore, prolonged CSF1R inhibition diminished the development of parenchymal plaques.
View Article and Find Full Text PDFChronic neuroinflammation represents a prominent hallmark of Alzheimer's disease (AD). While moderately activated microglia are pivotal in clearing amyloid beta (Aβ), hyperactivated microglia perpetuate neuroinflammation. Prior investigations have indicated that the elimination of ∼80% of microglia through a month-long inhibition of the colony-stimulating factor 1 receptor (CSF1R) during the advanced stage of neuroinflammation in 5xFamilial AD (5xFAD) mice mitigates synapse loss and neurodegeneration without impacting Aβ levels.
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- The study investigated COVID-19 vaccination rates among nurses in long-term care facilities in Germany, revealing that 80.6% were vaccinated, driven by facility requirements and protective measures for residents.
- Key factors influencing vaccination status included older age, full-time employment, COVID-19 deaths at the facility, and regional location; nurses with negative vaccination status often considered leaving their jobs.
- Results highlight the need for more research to understand vaccination decisions among nursing staff, which can inform future targeted vaccination campaigns in long-term care settings.
Article Synopsis
- * Specifically, MI admissions decreased by 22.5% and stroke admissions fell by 15.1% during the pandemic, with differing effects noted between types of MI (NSTEMI vs. STEMI).
- * Despite the reduction in admissions, the fatality risk for MI remained similar over the years, while there was an increased risk of death for hemorrhagic stroke cases; these findings highlight the serious implications for the vulnerable LTCF population.
Article Synopsis
- - Extracellular vesicles (EVs) from neural stem cells (NSC-EVs), astrocytes (ADEVs), and microglia (MDEVs) show potential for treating traumatic brain injury (TBI), with NSC-EVs and ADEVs having shown neuroprotective effects and improving motor and cognitive functions.
- - Although NSC-EVs and ADEVs primed with growth factors may have enhanced therapeutic benefits, the effectiveness of naïve MDEVs in TBI treatment remains unclear, with some findings indicating mixed results for activated MDEVs.
- - Clinical application of EV therapies is not yet viable; more research is required to assess the long-term effects, optimal administration methods, and proper isolation techniques for