Publications by authors named "C Hellriegel"
Background And Objectives: Test-to-stay concepts apply serial testing of children in daycare after exposure to SARS-CoV-2 without use of quarantine. This study aims to assess the safety of a test-to-stay screening in daycare facilities.
Methods: 714 daycare facilities and approximately 50 000 children ≤6 years in Cologne, Germany participated in a SARS-CoV-2 Pool-polymerase chain reaction (PCR) screening from March 2021 to April 2022.
Article Synopsis
- Understanding the mRNA life cycle involves studying the dynamics and composition of mRNPs (messenger ribonucleoproteins), and techniques like fluorescence correlation spectroscopy (FCS) and cross-correlation spectroscopy (FCCS) are effective tools for this purpose.
- FCS can analyze mRNPs in cell lysates, which mimic live cell conditions and allow for detailed studies of mRNP interactions and responses to treatments.
- FCCS can confirm known RNA interactions and measure the overlap of molecules within mRNPs, enhancing our understanding of their complexity and providing new ways to quantitatively analyze these structures.
Small cytoplasmic mRNP granules are implicated in mRNA transport, translational control, and decay. Using super-resolution microscopy and fluorescence correlation spectroscopy, we analyzed the molecular composition and dynamics of single cytoplasmic YBX1_IMP1 mRNP granules in live cells. Granules appeared elongated and branched, with patches of IMP1 and YBX1 distributed along mRNA, reflecting the attachment of the two RNA-binding proteins in cis.
View Article and Find Full Text PDFQuantum dots (QDs; 1 to 10 nm) were recently synthesized by sol-gel and used as nonagglomerated nanoparticles in adhesive resin. The sol-gel process presented a low yield and resulted in a liquid product without stability. In this study, an imidazolium ionic liquid (IL; 1- n-butyl-3-methylimidazolium tetrafluoroborate, BMI.
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