Publications by authors named "C Hellec"
Article Synopsis
- The Golgi apparatus is a vital organelle responsible for processing proteins, and this study focused on the distribution of glycosyltransferases within it using advanced imaging techniques.
- Researchers discovered that even glycosyltransferases thought to be in the same compartment have unique localizations influenced by their N-terminal regions.
- The findings suggest that these N-terminal regions are critical for determining where glycosyltransferases are located, enhancing our understanding of Golgi organization and potentially informing clinical strategies for protein glycosylation.
Ultrasound is currently recommended as the first-line examination for abdominal symptoms in children. However, a pediatric radiologist is not always available on site, especially during on-call duty. This study was aimed at evaluating the reliability of an innovative 3-D virtual abdominal tele-ultrasonography in this context.
View Article and Find Full Text PDFHeparan sulfate 3--sulfotransferases (HS3STs) catalyze the maturation step of heparan sulfate (HS) 3--sulfation. This modification is relatively rare. Moreover, only a few biological processes have been described to be influenced by 3--sulfated HS, and few ligands have been identified so far.
View Article and Find Full Text PDFBackground: Heparan sulfate (HS) 3-O-sulfation can be catalysed by seven 3-O-sulfotransferases (HS3STs) in humans, still it is the rarest modification in HS and its biological function is yet misunderstood. HS3ST2 and HS3ST3B exhibit the same activity in vitro. They are however differently expressed in macrophages depending on cell environment, which suggests that they may be involved in distinct cellular processes.
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