Publications by authors named "C Heilbronner"
Acute chest syndrome (ACS) is a leading cause of morbimortality in sickle cell disease (SCD). In this prospective observational study, we investigated sputum interleukin-6 (IL-6) level as an ACS severity marker during 30 ACS episodes in 26 SCD children. Sputum IL-6 levels measured within the first 72 h of hospitalisation for ACS were significantly higher in patients with oxygen requirement ≥2 L/min, ventilation (invasive and/or non-invasive) length ≥5 days, bilateral and/or extensive opacities on chest X-ray or erythrocytapheresis requirement.
View Article and Find Full Text PDFBackground: Continuous venovenous hemodiafiltration (CVVHDF) is one of the treatments of critically ill children presenting severe acute liver failure. This affliction might be induced by HSV infection requiring a treatment by acyclovir. Continuous kidney replacement therapy (CKRT) can alter its pharmacokinetics, according to its physicochemical properties and CVVHDF settings.
View Article and Find Full Text PDFArticle Synopsis
- * The research analyzed 58 children with Reye Syndrome, finding that a significant 71% had a confirmed IMD, with Urea Cycle Disorders being the most common.
- * Key insights included the importance of early metabolic testing and considering Next-Generation Sequencing for diagnosis, indicating that specialized care is crucial for these patients.