A kaleidoscopic view of extracellular vesicles in lysosomal storage disorders.

Extracellular vesicles (EVs) are a heterogeneous population of stable lipid membrane particles that play a critical role in the regulation of numerous physiological and pathological processes. EV cargo, which includes lipids, proteins, and RNAs including miRNAs, is affected by the metabolic status of the parental cell. Concordantly, abnormalities in the autophagic-endolysosomal pathway, as seen in lysosomal storage disorders (LSDs), can affect EV release as well as EV cargo.

CDC6: A novel canine tumour biomarker detected in circulating extracellular vesicles.

Circulating nucleic acids and extracellular vesicles (EV) represent novel biomarkers to diagnose cancer. The non-invasive nature of these so-called liquid biopsies provides an attractive alternative to tissue biopsy-based cancer diagnostics. This study aimed to investigate if circulating cell cycle-related E2F target transcripts can be used to diagnose tumours in canine tumour patients with different types of tumours.

Hurdles in treating Hurler disease: potential routes to achieve a "real" cure.

Mucopolysaccharidoses (MPSs) are multiorgan devastating diseases for which hematopoietic cell transplantation (HCT) and, to a lesser extent, enzyme replacement therapy have substantially altered the course of the disease. Furthermore, they have resulted in increased overall survival, especially for Hurler disease (MPS-1). However, despite the identification of clinical predictors and harmonized transplantation protocols, disease progression still poses a significant burden to patients, although at a slower pace.

Toxocara vitulorum in suckling calves in The Netherlands.

A Dutch farmer with beef cattle and suckling calves noticed one of the calves suffering from diarrhoea and observed large white worms near the perineum. In the faeces of this calf, eggs of Toxocara vitulorum were found. The majority of the cows in the herd were of the Piemontese breed previously imported from southern France.

Intergenerational service learning: linking three generations: concept, history, and outcome assessment.

In August 2006, the Foundation for Long Term Care (Albany, New York) received funding for a variant on service learning in elder care in which Boomers, other older adults, as well as college students would jointly engage in service-learning projects designed to address community needs in five different college towns and cities. This article reviews the historical antecedents to this project describing how it evolved from service of youth for the benefit of elders to the conceptualization of intergenerational service learning as service with elders. This new conceptualization ties in with Erikson's concept of generativity and the rising interest in civic engagement among elders.