Publications by authors named "C Hayes"
Article Synopsis
- Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are liver diseases that damage bile ducts, leading to bile accumulation, liver injury, and increased risk of liver failure; current treatments are limited, especially for PSC.
- Ursodeoxycholic acid is the first-line treatment for PBC, but many patients do not respond fully, indicating a need for better therapies; pruritus (itching) is a common and severe symptom due to cholestasis that is often inadequately treated.
- The review examines the use of PPAR agonists, a type of medication that targets liver metabolism, as potential second-line treatments for PBC and PSC, highlighting recent FDA approvals for
Purpose: Postsustained virologic response (SVR) screening following clinical guidelines does not address individual risk of hepatocellular carcinoma (HCC). Our aim is to provide tailored screening for patients using machine learning to predict HCC incidence after SVR.
Methods: Using clinical data from 1,028 SVR patients, we developed an HCC prediction model using a random survival forest (RSF).
Mismatch repair (MMR) deficiency can be indicative of Lynch syndrome (LS) and guide treatment with immune checkpoint inhibitors. Colorectal cancers (CRCs) and endometrial cancers (ECs) are routinely screened to identify LS, primarily using immunohistochemistry (IHC) or microsatellite instability (MSI) testing, but concordance between these methods is variable in ECs. Here, we investigate this variability in 361 ECs from the Ohio OCCPI/OPTEC ( = 196) and Manchester PETALS ( = 165) trials, where concordance between assays differed significantly.
View Article and Find Full Text PDFHeterotopic Ossification After Shoulder Arthroplasty: A Systematic Review.
J Am Acad Orthop Surg
December 2024
Article Synopsis
- Shoulder arthroplasty is becoming more common, but heterotopic ossification (HO) is a less investigated complication that involves abnormal bone growth in soft tissues after surgery.
- A systematic review analyzed six studies involving over 1,000 patients, finding that HO developed in 28% of cases, with men at a higher risk, and most instances were asymptomatic.
- The review found no significant differences in recovery for patients with or without HO and indicated that nonsteroidal anti-inflammatory drugs were not effective in preventing HO formation after shoulder surgery.