Publications by authors named "C Harrer"
Background: Managing acute vertigo/dizziness for inpatients requires valid communication between the various healthcare professionals that triage such life-threatening presentations, yet there are no current scaling methods for managing such acute vertigo symptoms for inpatients.
Objective: To describe the development and validation of the Krems Acute Vertigo/Dizziness Scale (KAVEDIS), a new instrument for tracking subjective symptoms (vertigo, dizziness) and gait impairment across four unique vestibular diagnoses (Menière's disease, benign paroxysmal positional vertigo, peripheral vestibular hypofunction, and vestibular migraine) over a one-year period after inpatient hospital admission.
Methods: Retrospective data collection study from KAVEDIS scale and chart documentation.
Licensed vaccines against the Middle East respiratory syndrome coronavirus (MERS-CoV), an emerging pathogen of concern, are lacking. The modified vaccinia virus Ankara vector-based vaccine MVA-MERS-S, expressing the MERS-CoV-spike glycoprotein (MERS-S), is one of 3 candidate vaccines in clinical development and elicits robust humoral and cellular immunity. Here, we identified for the first time a MERS-S-specific CD8+ T-cell epitope in an HLA-A*03:01/HLA-B*35:01-positive vaccinee using a screening assay, intracellular cytokine staining, and in silico epitope prediction.
View Article and Find Full Text PDFImmunoglobulin A (IgA) is the most abundant antibody isotype produced across mammals and plays a specialized role in mucosal homeostasis . Constantly secreted into the lumen of the intestine, IgA binds commensal microbiota to regulate their colonization and function with unclear implications for health. IgA deficiency is common in humans but is difficult to study due to its complex aetiology and comorbidities .
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- The study investigates the effects of two thiamine substitution (TS) regimens on thiamine blood levels and cognitive function in patients with alcohol use disorder (AUD).
- Fifty patients undergoing treatment were evaluated for thiamine pyrophosphate (TPP) levels and cognitive function over an 8-week period, comparing oral TS with and without prior intravenous TS.
- Results showed significant increases in TPP levels in both groups, with no notable difference between the two regimens, and a correlation was found between the response to TS and memory performance, suggesting oral TS may be sufficient to help prevent cognitive decline in AUD.