Publications by authors named "C Harden"
Article Synopsis
- This project analyzed if cranial ischaemic complications in giant cell arteritis (GCA) patients were linked to existing cardiovascular (CV) risk factors, CV diseases, or genetic predispositions.
- The study examined data from 1946 GCA patients, finding that 17% had cranial ischaemic issues, with significant factors including age (especially those ≥80) and hypertension, while anticoagulant therapy seemed to reduce risk.
- The research indicated potential genetic factors affecting CV-related traits and suggested that immune and coagulation pathways may play a role in these complications, warranting further investigation before applying findings to clinical settings.
There is a reciprocal relationship between epilepsy and reproductive endocrine disorders. Seizures and anti-seizure medications (ASMs) can contribute to reproductive and endocrine dysfunction and reproductive dysfunction may exacerbate seizures. Epilepsy via neuroendocrine mechanisms affects the hypothalamic-pituitary-ovarian (HPO) axis, disrupting the regulation of gonadotropin secretion, and resulting in dystrophic effects on the ovaries and early menopause.
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- 74 species of Anillini in two genera have been identified in the eastern U.S., with DNA sequences supporting a clarified systematic framework for the genus.
- The study identifies sixteen species groups based on new findings in male protarsi and spermathecal duct variation, as well as the first descriptions of Nearctic anilline larvae.
- Nine new species are described, expanding the South Carolina fauna significantly, showcasing unique endogean lineages and male sexual traits, which highlight the ecological and biogeographical importance of Anillini.
Importance: Many patients with focal epilepsy experience seizures despite treatment with currently available antiseizure medications (ASMs) and may benefit from novel therapeutics.
Objective: To evaluate the efficacy and safety of XEN1101, a novel small-molecule selective Kv7.2/Kv7.
Introduction: Maintaining seizure control with lamotrigine is complicated by altered pharmacokinetics and existence of subpopulations in whom clearance increases or remains constant during pregnancy.
Objective: Our objective was to characterize the potential for particular dosing scenarios to lead to increased seizure risk or toxicity.
Methods: Lamotrigine pharmacokinetic parameters obtained from our previous study were applied to a one-compartment model structure with subpopulations (75:25%) exhibiting different clearance changes.