Publications by authors named "C Hammerberg"
Alterations of the collagen, the major structural protein in skin, contribute significantly to human skin connective tissue aging. As aged-appearing skin is more common in diabetes, here we investigated the molecular basis of aged-appearing skin in diabetes. Among all known human matrix metalloproteinases (MMPs), diabetic skin shows elevated levels of MMP-1 and MMP-2.
View Article and Find Full Text PDFIncreased expression of matrix metalloproteinase-1 (MMP-1) and reduced production of type I collagen by dermal fibroblasts are prominent features of aged human skin. We have proposed that MMP-1-mediated collagen fibril fragmentation is a key driver of age-related decline of skin function. To investigate this hypothesis, we constructed, characterized, and expressed constitutively active MMP-1 mutant (MMP-1 V94G) in adult human skin in organ culture and fibroblasts in three-dimensional collagen lattice cultures.
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- Fractionated ablative laser resurfacing is a popular skin treatment that shows clinical results similar to traditional fully ablative laser resurfacing, particularly for photodamaged skin.
- A study compared the molecular changes in skin after treatment with both types of CO(2) lasers on 34 adult volunteers, using advanced techniques to assess the results.
- Findings indicated that while both treatments stimulate significant skin improvement and collagen production, fractionated laser treatment results in about 40% to 50% of the collagen induction seen with fully ablative treatments, yet it is still an effective option for enhancing skin texture.