Publications by authors named "C Halleux"
Controlled local delivery of therapeutics (small molecule drug crystals or biologics) for knee-associated diseases such as osteoarthritis necessitates patient compliance, ensuring that the injected depot does not trigger local tissue inflammation and immune responses. A local drug delivery strategy that releases drug at a controlled rate while ensuring minimal tolerability issues at the injection site would be an appealing paradigm in intra-articular (IA) therapies. Herein, we report the formulation development and characterization of surface modified PLGA microparticles (MPs) through the surface integration of a cationic lipid, DOTAP (1,2-Dioleoyl-3-trimethylammonium propane).
View Article and Find Full Text PDFOnchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia.
Parasit Vectors
March 2024
Article Synopsis
- The study examined the safety and effectiveness of moxidectin versus ivermectin in treating Onchocerca volvulus infections, particularly focusing on microfilariae levels and ocular adverse reactions in patients with high microfilarial counts.
- Data were collected from 1,463 participants, and results showed that both treatments had similar impacts on ocular microfilariae levels (mfAC) and resulted in Mazzotti reactions in about 10-12% of participants, with factors like gender and pre-treatment mfAC influencing the severity of reactions.
- The findings suggest that while both treatments are effective, women and those with higher mfAC levels may be at increased risk for more severe ocular reactions post
The success of the visceral leishmaniasis (VL) elimination program largely depends on cost-effective vector control measures. Our goal was to investigate the longevity of the efficacy of insecticidal wall painting (IWP), a new vector control tool, compared with a routine indoor residual spraying (IRS) program for reducing the VL vector density in Bangladesh. This study is the extension of our recent IWP study for VL vector management in Bangladesh, which was undertaken in seven highly VL endemic villages of the Mymensingh district with a 12-month follow-up.
View Article and Find Full Text PDF