Publications by authors named "C H van Den Ende"
Objectives: To evaluate (1) the association between nailfold capillaroscopy pattern and 5-year risk for incident interstitial lung disease and (2) the association between transition in nailfold capillaroscopy pattern and risk of incident interstitial lung disease.
Methods: Data of adult patients from the EUSTAR database fulfilling the ACR-EULAR criteria with a disease duration ⩽5 years, having a scleroderma pattern at nailfold capillaroscopy with high-resolution computed tomography confirmed absence of interstitial lung disease (i.e.
Objectives: To explore patient characteristics associated with response to intramuscular methylprednisolone (MP) therapy in hand OA.
Methods: We performed an exploratory monocentric retrospective study. Patients with a clinical diagnosis of hand OA who visited our outpatient clinic between July 2016 and June 2021 and received at least once an intramuscular MP injection were included.
Introduction: Despite recommendations, non-surgical treatment modalities in knee and/or hip osteoarthritis (KHOA) are underused. An information campaign was developed targeting patients with early stage KHOA and healthcare professionals (HCPs) to optimise timing of referral to secondary care. This protocol describes the development and design of this information campaign and a randomised controlled trial (RCT) on its effectiveness in impacting healthcare utilisation.
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- The study aimed to differentiate osteoarthritis (OA) patients by analyzing their serum-induced cellular signaling patterns, using samples from knee OA patients, hand OA patients, and healthy controls.
- Results showed significant differences in cellular pathway activity based on the type of OA, with hand OA serum triggering higher MAPK-related AP1 activity, while knee OA serum affected other pathways related to ELK1-SRF, STAT1-STAT2, and SOX9.
- The findings suggest that the underlying mechanisms of OA differ between hand and knee OA, potentially paving the way for more targeted treatments based on specific OA endotypes.
Detection of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease using home monitoring in the Netherlands (DecreaSSc): a prospective, observational study.
Lancet Rheumatol
November 2024
Article Synopsis
- Patients with systemic sclerosis are at high risk for interstitial lung disease (ILD), which can lead to increased mortality, making early detection critical for better management and outcomes.
- The DecreaSSc study, conducted in the Netherlands, involved eligible patients using home spirometry to monitor lung function weekly for a year, comparing these results with hospital tests.
- The study aimed to determine how well home spirometry could identify a significant decline in lung function (≥5% decrease in forced vital capacity) and involved patient feedback throughout its design and execution.