[Insulin therapy using a portable pump in children. Apropos of a pediatric experience].

Experience accumulated with 17 pediatric patients with insulin-dependent diabetes mellitus treated with an insulin pump is reported. Follow-up exceeds four years in seven patients. A significant improvement in metabolic control was seen in only four patients and was confined to the first year of use of the pump.

[Degenerative complications of diabetes].

Even optimally treated insulin-dependent diabetes mellitus is responsible for a significant number of complications which impair daily activities and shorten life expectancy in most patients. The cause of these complications has been under investigation for many years. Substantial evidence supports the following 1) a role of high blood sugar levels which lead to glycosylation processes; 2) presence of disorders related to inadequate nutrition, and specifically excessive dietary intake of saturated fatty acids, rather than to insulin deficiency.

[Clinical value of the determination of serum IgE in allergy to cow's milk proteins in infants].

The serum IgE, that are associated to the process of the immediate allergy are studied in children presenting a clinical semiology suggestive of intolerance to the cow-milk proteins, in order to specify their contribution in the diagnosis and the follow-up of this disease. The serum IgE are determined by the PRIST method and the presence of the milk proteins specific IgE, by the RAST method. In infants (n = 80) fed with infant formula and less than 4 months old, if it obviously appeared an increase of the global IgE with the age, on the other hand, no one had specific IgE to the cow-milk proteins.

[Neonatal hypoglycemia caused by hyperinsulinism and subsequent epilepsy].

A historical cohort study was undertaken to determine the risk of epilepsy in a population of 18 newborns with neonatal hypoglycemia due to insulin excess. Follow-up was 3 years 8 months (range 7 years-1 year 3 months). Insulin excess was associated with maternal diabetes in 13 infants, with an isolated macrosomia in 2 infants, in one case with probable Langerhans hyperplasia, and in 2 newborns only prolonged beta-sympathomimetic therapy was the possible cause of insulin excess.