Publications by authors named "C H Van Werkhoven"
Vertebral osteomyelitis in patients with infective endocarditis: prevalence, risk factors and mortality.
Eur J Clin Microbiol Infect Dis
January 2025
Purpose: Infective endocarditis (IE) can be complicated by vertebral osteomyelitis (VO). This study investigates risk factors associated with VO in patients with infective endocarditis, and 6-month mortality and relapse rates in patients with IE and concomitant VO.
Methods: We performed a observational study in two hospitals between September 2016 and October 2022.
Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study.
Antimicrob Resist Infect Control
November 2024
Article Synopsis
- * A study at Haukeland University Hospital analyzed 523 patients, finding that while a high percentage received antibiotics quickly, only 20.2% adhered to the recommended duration of treatment, with certain factors linked to longer therapy times.
- * The findings indicated that most deviations from guidelines were due to planned post-discharge treatments, highlighting a need for better adherence to antibiotic duration guidelines, despite effective initial empirical therapy choices.
Objectives: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the intensive care unit (ICU). The aim of this study was to determine the incidence of PA ICU pneumonia (PAIP) and to quantify its independent association with PA colonization at different body sites.
Methods: Adult patients on mechanical ventilation at ICU admission were prospectively enrolled across 30 European ICUs.
Objectives: Previous research has suggested beneficial heterologous effects of the Bacillus Calmette-Guérin (BCG) vaccine on non-mycobacterial infections and other immune-mediated diseases. During the COVID-19 pandemic, randomized controlled trials BCG-PRIME (n = 5349) and BCG-CORONA-ELDERLY (n = 1907) investigated the impact of BCG on SARS-CoV-2 infections in older individuals. We extended the follow-up in these studies by one year (BCG-Long Term study), to assess the overall effects of BCG vaccination on infectious and immune-mediated diseases in individuals aged over 60.
View Article and Find Full Text PDFBackground: In community-acquired pneumonia (CAP), the role of biomarkers to shorten duration of antibiotic treatment has not been firmly established. We assessed the effectiveness of active feedback of treatment algorithms based on procalcitonin (PCT) and C-reactive protein (CRP), compared to standard care, on the duration of antibiotic treatment in patients hospitalized with community-acquired pneumonia (CAP) in non-ICU wards.
Methods And Findings: We performed a randomised, open label, parallel group, multi-centre trial in 3 Dutch teaching hospitals.