Total Synthesis of (-) and (+)-Zingibergingerols A.

The first total synthesis of both of the enantiomers of Zingibergingerol A has been accomplished. The distinctive 3,7,9-trioxabicyclo[4.2.

Synthesis of Tetracyclic Benzoxazolo-indol-3-ones from Isatogens and Arynes through a [3 + 2]-Cycloaddition and Skeletal Reorganization.

The construction of an unprecedented tetracyclic benzoxazolo-indol-3-one scaffold has been executed through the [3 + 2]-cycloaddition of isatogens with arynes. The initially formed benzisoxazolo-indol-3-one intermediate undergoes a skeletal reorganization through a 1,3-sigmatropic shift/retro-Mannich reaction with the net formation of one C-N and two C-O bonds. The Lewis acid-catalyzed allylation of some of the resulting benzoxazolo-indol-3-ones resulted in oxazepino-indolones with promising photophysical properties.

Nanoengineered pure Fe in a citrate matrix (Fe-CIT) with significant and tunable magnetic properties.

This work demonstrates the synthesis and characterization of Fe nanoparticles surrounded by a citrate (CIT) matrix prepared at various temperatures and concentrations of metal, capping agent and reducing agent at standard conditions. We study the effect of reactant ratio and reaction temperature on the magnetization of the produced nanoparticles and their crystal structure. We found that for optimal metal concentrations, magnetic saturation increases with increase in the concentration of capping and reducing agents but decreases as the temperature of the reaction increases.

Intramolecular Nitrone Interrupted Click Reaction.

We document the intramolecular interception of a Cu-catalyzed azidoalkyne cycloaddition employing a suitably placed nitrone group, providing a simple route to the unprecedented spiro-polyheterocyclic scaffold. The reaction is comprised of a Cu-catalyzed [3 + 2]-cycloaddition of (2-azidoaryl)isatogen with a terminal alkyne and the intramolecular trapping of the transient Cu-triazolide intermediate with the isatogen, with a net formation of one C-C and two C-N bonds and the new heterocyclic ring being spiro-annulated.

Synthesis, characterization, and crystal structure of 2-(2-azido-phen-yl)-3-oxo-3-indole 1-oxide.

An attempt to explore the reactivity of the nitro group in the presence of gold catalysis in comparison to the azide group yielded intriguing results. Surprisingly, only the nitro group exhibited reactivity, ultimately giving rise to the formation of the title isatogen, CHNO. In the crystal structure, weak C-H⋯O hydrogen bonds and π-π stacking inter-actions link the mol-ecules.