Publications by authors named "C H Toh"
We herein report a case of IgG4-related autoimmune hepatitis (AIH) in a patient with a history of type 1 autoimmune pancreatitis. A 56-year-old man presented with fatigue and jaundice at our hospital. A blood biochemistry analysis revealed significant liver dysfunction, positive results for antinuclear antibodies, and high serum IgG4 levels.
View Article and Find Full Text PDFThe aim of this study was to develop a model for predicting the risk of postoperative temporomandibular joint osteoarthritis (TMJOA) in patients receiving a segmental or marginal mandibulectomy for oral cavity cancer . A total of 371 patients with buccal or gingival cancer who underwent mandibulectomy were included in this retrospective cohort study. Demographic data, computed tomography, and magnetic resonance images were reviewed.
View Article and Find Full Text PDFArticle Synopsis
- Understanding sleep's impact on the glymphatic system and brain networks is key to addressing memory decline in aging.
- Researchers studied 72 older adults using MRI and sleep measurements, finding a link between glymphatic function (DTI-ALPS) and sleep quality.
- Results indicated that poor sleepers had disrupted neural connections, implicating sleep quality in cognitive health and memory function.
Article Synopsis
- - Severe ADAMTS13 deficiency (<10 iu/dL) is a key indicator of thrombotic thrombocytopenic purpura (TTP), leading to serious health issues like microthrombi and platelet aggregation.
- - The article explores the consequences of low ADAMTS13 levels not only during acute TTP episodes but also in patients during clinical remission, indicating ongoing risks.
- - Research indicates that low ADAMTS13 activity may also affect vascular health in diseases beyond TTP, suggesting potential benefits from recombinant ADAMTS13 therapy in treating other thrombotic conditions.
There has been an expansion in our understanding of the multifaceted roles of circulating blood cells in regulating haemostasis and contributing to thrombosis. Notably, there is greater recognition of the interplay between coagulation with inflammation and innate immune activation and the contribution of leucocytes. The full blood count (FBC) is a time-honoured test in medicine; however, its components are often viewed in isolation and without consideration of their haemostatic and thrombotic potential.
View Article and Find Full Text PDF