Publications by authors named "C H Saely"
Background: Both chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) confer a high risk of cardiovascular disease and mortality. These entities frequently coincide. The separate and joint impact of CKD and T2DM on the risk of major cardiovascular events (MACE) and survival is unclear.
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- Remnant cholesterol (RC) has gained attention as a potential lipid factor for assessing cardiovascular risk, though previous data were often imprecise due to factors like non-fasting samples.
- In a study involving 1,474 CAD patients, researchers measured RC using strictly fasting samples and tracked all-cause and cardiovascular mortality, along with major adverse cardiovascular events (MACE), over an average follow-up of 11.6 years.
- The results indicated that higher RC levels were significantly associated with increased risks of all-cause mortality, cardiovascular mortality, and MACE, regardless of patient demographics or statin use, establishing RC as a reliable indicator of residual risk in CAD patients.
Aim: Over recent years, therapy options and strategies for type 2 diabetes mellitus (T2DM) have developed substantially. This study investigated glucose-lowering treatment in patients with high cardiovascular risk over three decades.
Materials And Methods: A total of 2158 patients undergoing elective coronary angiography at a tertiary care hospital in Europe were included in three sequential observational studies (OS): OS1 (1999-2000; n = 672), OS2 (2005-2008; n = 1005) and OS3 (2022-2023; n = 481).
Article Synopsis
- Older adults still face high risks of severe outcomes from COVID-19, even with the milder Omicron variant, due to weakened immune responses and insufficient data on antibody efficacy.
- A study involving 785 older patients found that those with low antibody levels (< 1,200 BAU/mL) had significantly higher mortality and critical care needs compared to those with higher levels.
- The findings suggest that monitoring antibody levels might be more effective than relying solely on vaccination status to protect older adults from severe COVID-19 outcomes.