Associations on the Fly, a new feature aiming to facilitate exploration of the Open Targets Platform evidence.

Motivation: The Open Targets Platform (https://platform.opentargets.org) is a unique, comprehensive, open-source resource supporting systematic identification and prioritisation of targets for drug discovery.

Evaluating the Retreatability of Hydraulic Calcium Silicate-Based Root Canal Sealer Using Root Canal Instrumentation-An Study.

Aim: This study aimed to compare the retreatability of hydraulic calcium silicate-based (HCSB) and epoxy resin-based sealers in single-rooted mandibular premolars, with a specific focus on sealer remnants and retreatment duration.

Methodology: Sixty mandibular premolars were biomechanically prepared and obturated with BioRoot RCS, MTA Fillapex, or AH Plus. After a one-month period, the gutta-percha was removed and the specimens were analyzed under a stereomicroscope.

Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype.

Sequencing of human patient tumors has identified recurrent missense mutations in genes encoding core histones. We report that mutations that convert histone H3 amino acid 50 from a glutamate to a lysine (H3E50K) support an oncogenic phenotype. Expression of H3E50K is sufficient to transform human cells as evidenced by an increase in cell migration and invasion, and an increase in proliferation and clonogenicity.

Nutritional Anemia Reductions Due to Food Fortification Among Women of Childbearing Age: A Literature Review and Bayesian Meta-Analysis.

Food fortification can deliver essential micronutrients to populations at a large scale, thereby reducing nutritional anemia. This study aimed to review and meta-analyze the literature on the impact of wheat flour, maize flour, rice, and oil (singly or combined) fortification on women's (10-49 years) hemoglobin and anemia. A search of 17 databases yielded 2284 results.