Publications by authors named "C H Matthews"
Description: In July 2024, the U.S. Department of Veterans Affairs (VA) and U.
View Article and Find Full Text PDFThe development of new and improved antiretroviral therapies that allow for alternative dosing schedules is needed for people living with HIV-1. Islatravir is a deoxyadenosine analog in development for the treatment of HIV-1 that suppresses HIV-1 replication via multiple mechanisms of action, including reverse transcriptase translocation inhibition and delayed chain termination. Islatravir is differentiated from other HIV-1 antiretrovirals by its high potency, long , broad tissue distribution, and favorable drug resistance profile.
View Article and Find Full Text PDFArticle Synopsis
- The study compares total laparoscopic hysterectomy (TLH) and laparoscopic supracervical hysterectomy (LSCH) during minimally invasive sacrocolpopexy for treating uterovaginal prolapse.
- Results showed no significant difference in overall recurrence of prolapse between the two methods, but TLH had lower odds of recurrence in multivariable analysis.
- TLH had a higher proportion of mesh exposures with lightweight mesh, but this finding wasn't significant after adjusting for other factors.
Importance: Limited evidence exists on the effect of combined native tissue vaginal prolapse repair with midurethral sling on urgency urinary incontinence (UUI) symptoms.
Objectives: This study aimed to evaluate the effect of combined native tissue vaginal prolapse repair with midurethral sling on UUI symptoms at 12 months postoperatively and identify risk factors for persistent UUI.
Study Design: This secondary analysis utilized data from a randomized trial comparing retropubic versus single-incision slings in women undergoing treatment of stress incontinence and vaginal prolapse with native tissue vaginal repair and midurethral sling.