Tumor suppressive role of the antimicrobial lectin REG3A targeting the O -GlcNAc glycosylation pathway.

Background And Aims: Antimicrobial proteins of the regenerating family member 3 alpha (REG3A) family provide a first line of protection against infections and transformed cells. Their expression is inducible by inflammation, which makes their role in cancer biology less clear since an immune-inflammatory context may preexist or coexist with cancer, as occurs in HCC. The aim of this study is to clarify the role of REG3A in liver carcinogenesis and to determine whether its carbohydrate-binding functions are involved.

Helical coil design with controlled dispersion for bunching enhancement of protons generated by the target normal sheath acceleration.

The quality of the proton beam produced by target normal sheath acceleration (TNSA) with high-power lasers can be significantly improved with the use of helical coils. While they showed promising results in terms of focusing, their performances in terms of the of cut-off energy and bunching stay limited due to the dispersive nature of helical coils. A new scheme of helical coil with a tube surrounding the helix is introduced, and the first numerical simulations and an analytical model show a possibility of a drastic reduction of the current pulse dispersion for the parameters of high-power-laser facilities.

[Memories of the 13-November 2015 terrorist attacks: what discourse analysis can teach us].

The Programme 13-Novembre aims to analyze the individual and collective memory of the terrorist attacks of November 13, 2015. At its heart is the Étude 1000, which is to gather the same 1000 people in audiovisual interviews four times in 10 years. Having the transcripts at our disposal, we choose here to show the importance of discourse analysis by recalling its theoretical foundations, to present one of the tools allowing this statistical analysis, the Correspondence Factor Analysis, and to use it to analyze the sub-corpus of interviews conducted at a distance from the Paris events, with 76 inhabitants of the Metz region.