Ru(II)-arene azole complexes as anti-amyloid-β agents.

With the recent clinical success of anti-amyloid-β (Aβ) monoclonal antibodies, there is a renewed interest in agents which target the Aβ peptide of Alzheimer's disease (AD). Metal complexes are particularly well-suited for this development, given their structural versatility and ability to form stabile interactions with soluble Aβ. In this report, a small series of ruthenium-arene complexes were evaluated for their respective ability to modulate both the aggregation and cytotoxicity of Aβ.

Diastereoselective Synthesis of the HIV Protease Inhibitor Darunavir and Related Derivatives via a Titanium Tetrachloride-Mediated Asymmetric Glycolate Aldol Addition Reaction.

Darunavir is a potent HIV protease inhibitor that has been established as an effective tool in the fight against the progression of HIV/AIDS in the global community. The successful application of this drug has spurred the development of derivatives wherein strategic regions (e.g.

Microplastic and adhesive free, multifunctional, circular economy approach-based biomass-derived drinking straws.

Generation of voluminous single-use plastic waste and byproducts from agricultural harvests such as rice straws (RSs) are major global challenges due to their disposal issues, contributing to greenhouse gas emissions, and affecting the ecological system with threats to human health. A scalable, low-cost, and eco-friendly strategy for fabricating cellulose-silica-based drinking straws, free from microplastics and adhesive, through strategic valorization of RS is reported. Functionalization by delignification--crosslinking of RS leads to development of straws with high water stability (∼5 days), solvothermal stability (0°C-95°C), tensile strength (128 MPa), low migration values (<60 mg/kg), improved biodegradability (∼126 days) with reduced wettability and hydrophobicity.

A versatile beamline for soft x-ray reflectivity, absorption, and fluorescence measurements at Indus-2 synchrotron source.

A versatile beamline for performing reflectivity, fluorescence, and absorption experiments in the soft x-ray region of 100-1500 eV is commissioned on a bending magnet port of the Indus-2 synchrotron source. A high vacuum 2-axis reflectometer with x, y, and z sample scanning stages is installed. This reflectometer is used to measure the reflectivity of large samples up to 300 mm in length and 5 kg in weight.

A Real-World Observational Study to Evaluate the Safety and Effectiveness of Fluticasone Furoate-Oxymetazoline Fixed Dose Combination Nasal Spray in Patients with Allergic Rhinitis.

Background: Allergic rhinitis (AR) has shown an increasing prevalence leading to a considerable medical and social burden. Nasal congestion is the cardinal symptom of AR, and the upper respiratory tract is most affected by this long-lasting ailment. Intranasal corticosteroids alleviate nasal congestion, along with other symptoms of AR, but their effect is not evident immediately.