Beta-glucosidase 1 (GBA1) is a second bile acid β-glucosidase in addition to β-glucosidase 2 (GBA2). Study in β-glucosidase deficient mice and humans.

Beta-glucosidase 1 (GBA1; lysosomal glucocerebrosidase) and β-glucosidase 2 (GBA2, non-lysosomal glucocerebrosidase) both have glucosylceramide as a main natural substrate. The enzyme-deficient conditions with glucosylceramide accumulation are Gaucher disease (GBA-/- in humans), modelled by the Gba-/- mouse, and the syndrome with male infertility in the Gba2-/- mouse, respectively. Before the leading role of glucosylceramide was recognised for both deficient conditions, bile acid-3-O-β-glucoside (BG), another natural substrate, was viewed as the main substrate of GBA2.

Imaging hemorrhagic stroke with magnetic induction tomography: realistic simulation and evaluation.

Magnetic induction tomography (MIT) is a noncontact method for detecting the internal conductivity distribution of an object. This technology has the potential to be used in the biomedical area to check bio-impedance change inside the human body, for example to detect hemorrhage in the human brain. In this study the hemorrhagic stroke detectability with a 16-channel MIT system operating at 10 MHz was evaluated.

A measurement system and image reconstruction in magnetic induction tomography.

Magnetic induction tomography (MIT) is a technique for imaging the internal conductivity distribution of an object. In MIT current-carrying coils are used to induce eddy currents in the object and the induced voltages are sensed with other coils. From these measurements, the internal conductivity distribution of the object can be reconstructed.

A comparison of continuous wave Doppler radar to impedance cardiography for analysis of mechanical heart activity.

The paper compares the data obtained from a continuous wave Doppler radar sensor based on a commercially available microwave motion sensor KMY24 to an impedance cardiograph measured using a Cardiac Output Monitor (Medis Niccomo). Both sensors are used to analyze the mechanical activity of the heart. System parameters, signal content and robustness are discussed.

A comparison of sensors for minimizing the primary signal in planar-array magnetic induction tomography.

In magnetic induction tomography reducing the influence of the primary excitation field on the sensors can provide a significant improvement in SNR and/or allow the operating frequency to be reduced. For the purposes of imaging, it would be valuable if all, or a useful subset, of the detection coils could be rendered insensitive to the primary field for any excitation coil activated. Suitable schemes which have been previously suggested include the use of axial gradiometers and coil-orientation methods (Bx sensors).