Publications by authors named "C H Hinze"
Article Synopsis
- Familial Mediterranean fever (FMF) is a genetic condition marked by inflammation episodes, usually treated with colchicine to prevent complications like amyloid A amyloidosis, but its necessity for heterozygous patients is debated.* -
- A study analyzed 747 FMF patients' demographic and inflammatory biomarker data, revealing that heterozygous patients generally exhibited lower inflammatory markers compared to those with more severe genetic variants.* -
- The findings suggest that certain biomarkers (S100A8/A9 and S100A12) can indicate disease activity, and some heterozygous patients may be eligible to safely stop colchicine treatment.*
Article Synopsis
- The study explores the role of 2,3-bisphosphoglycerate mutase (BPGM) in the kidney, highlighting its upregulation during acute kidney injury in both mice and humans.
- Using a specialized mouse model, researchers found that BPGM is mainly located in the distal nephron and its knockout led to rapid kidney injury and structural damage after just four days.
- The absence of BPGM disrupts crucial metabolic processes, elevating oxidative stress and inflammation while linking stress responses between different parts of the nephron, underscoring its importance in kidney function.
Article Synopsis
- CTLA-4 and PD-1 are immune checkpoints crucial for immunotherapy, with their interactions mediated by CD80 and PD-L1 ligands.
- The study reveals that CTLA-4 selectively interacts with CD80 without displacing PD-L1, and that this interaction depends on the structure of CTLA-4 to properly orient CD80.
- CTLA-4's method of trans-endocytosis is shown to effectively release PD-L1 across different conditions, highlighting its role in promoting PD-L1 availability by manipulating membrane protein orientation and interactions.
is a food-grade lactic acid bacterium widely used in the food and beverage industry. Recently, this probiotic organism has been applied as a biofactory for the production of pharmaceutical and food-related compounds, but existing promoters and expression vectors for the genetic engineering of rely on inefficient cloning strategies and are usually not well-characterized. We therefore developed a modular and standardized Golden Gate Assembly-based toolbox for the assembly of shuttle vectors from to .
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