Publications by authors named "C H Hinkin"
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15-90. The effects of dementia, mild cognitive impairment, Parkinson's disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals.
View Article and Find Full Text PDFArticle Synopsis
- Researchers in neuroscience are using Big Data to improve the reliability and replication of cognitive studies, focusing on memory testing.
- They conducted a mega-analysis with data from 53 studies, involving over 10,500 individuals, employing methods to harmonize data and reduce variability across different sites.
- Their findings show that large-scale data sharing can enhance the reproducibility of research in behavioral sciences, and they offer a free conversion tool for this purpose.
A preliminary set of analyses are presented, where workload was examined in 32 adults infected with the human immunodeficiency virus (HIV). Like the current COVID-19 pandemic (caused by the SARS-CoV-2 virus), HIV can produce a wide variety of symptoms, including various levels of cognitive dysfunction. In fact, a recent meta-analysis estimates that of the 39 million adults infected globally with HIV, 42.
View Article and Find Full Text PDFImportance: Despite more widely accessible combination antiretroviral therapy (cART), HIV-1 infection remains a global public health challenge. Even in treated patients with chronic HIV infection, neurocognitive impairment often persists, affecting quality of life. Identifying the neuroanatomical pathways associated with infection in vivo may delineate the neuropathologic processes underlying these deficits.
View Article and Find Full Text PDFObjective: Incidental learning and memory, as well as processing speed, were examined in human immunodeficiency virus (HIV)-positive adults and a seronegative control group.
Methods: Participants completed a computerized Symbol-Digit Modalities Test (cSDMT) with two blocked conditions: a set of trials with the standard symbol-digit pairings and the second set with a rearranged symbol-digit pairings.
Results: HIV-positive adults showed slower overall reaction time compared to the HIV-negative group.