Publications by authors named "C H Giorgio"
Background And Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterised by progressive biliary inflammation and fibrosis, leading to liver cirrhosis and cholangiocarcinoma. GPBAR1 (TGR5) is a G protein-coupled receptor for secondary bile acids. In this study, we have examined the therapeutic potential of BAR501, a selective GPBAR1 agonist in a PSC model.
View Article and Find Full Text PDFVulvar Lichen Sclerosus (VLS) is a chronic autoimmune disease that often leads to vulvodynia, a debilitating chronic pain condition in the vulvar region. Treating vulvodynia in the context of VLS presents a significant therapeutic challenge due to the lack of standardized protocols. This article presents a case series of 20 women treated with amitriptyline for vulvodynia secondary to VLS, accompanied by an extended review of the literature.
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- The dysbiotic gut microbiota and bile acids play a crucial role in the immune dysfunction seen in inflammatory bowel disease (IBD), as shown by changes in bile acid excretion and gut microbiota composition.
- Elevated primary bile acids and reduced secondary bile acids were linked to increased disease severity and inflammatory responses in IBD patients and murine colitis models.
- The study identified five specific bile acids that, when administered, could reverse colitis and intestinal dysbiosis, suggesting the potential for treatments targeting bile acid profiles in managing IBD.
Type 2 diabetes mellitus (T2D) is defined by chronic hyperglycemia due to insufficient insulin secretion or activity and decreased insulin sensitivity, known as insulin resistance (IR). This condition leads to oxidative stress and inflammation, increasing the risk of systemic inflammatory diseases. Obesity and a sedentary lifestyle are major risk factors for IR and T2D.
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