Publications by authors named "C H DOHLMAN"
Purpose: Ocular chemical injuries often cause uveal inflammation, upregulation of TNF-α at the limbus, and subsequent limbal stem cell (LSC) damage. In this study, we investigate the protective role of TNF-α suppression in LSC survival.
Methods: Corneal alkali injuries were performed using NaOH as previously described by our group.
Article Synopsis
- Late secondary glaucoma is a serious condition that can develop after surgeries, injuries, or infections, largely driven by TNF-α, which triggers cell death in the retina and damage in the optic nerve.
- The study tested the safety and effectiveness of two TNF-α inhibitors, adalimumab and infliximab, on rabbits, assessing both how well the drugs were tolerated and their ability to protect retinal cells after induced damage.
- Results showed that low doses of adalimumab and infliximab were safe and effective, with 4.0 mg of adalimumab providing strong protection against cell death shortly after injury.
Article Synopsis
- - This study developed a practical therapy using a thermosensitive drug delivery system (DDS) to treat ocular injuries, specifically delivering TNF-α and VEGF inhibitors to aid in eye recovery.
- - In tests on Dutch-belted pigmented rabbits, the dual DDS led to sustained delivery of drugs over three months, resulting in significant improvements in corneal healing, reduced immune cell infiltration, and prevention of nerve cell loss compared to control treatments.
- - The results showed that the combination therapy effectively inhibited corneal neovascularization, accelerated healing, and was safe for use, demonstrating the potential for this method in clinical applications for ocular protection post-injury.
Limbal stem cell (LSC) deficiency is a frequent and severe complication after chemical injury to the eye. Previous studies have assumed this is mediated directly by the caustic agent. Here we show that LSC damage occurs through immune cell mediators, even without direct injury to LSCs.
View Article and Find Full Text PDFGenerativity refers to the desire to pass on one's skills, knowledge, and wisdom to future generations; this may be a clear indicator of the likelihood of older adults investing time and effort in engagement with their grandchildren. This cross-sectional study examines the relationship between generative beliefs and an index of multiple potential grandparenting activities. The data come from a convenience sample of 79 grandparents (aged 55+) living in Sri Lanka, a society experiencing rapid growth in its population of older adults.
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