Publications by authors named "C H D Fall"
Background: Acinetobacter baumannii, particularly carbapenem-resistant strains (CRAB), poses a major concern in the fight against antimicrobial resistance (AMR), identified as a top-priority pathogen by the World Health Organization (WHO). A. baumannii has intrinsic resistance to several antibiotics, including penicillin, cephalosporins, chloramphenicol, and fosfomycin, but the development of AMR has led to the emergence of extremely drug-resistant and pan-resistant isolates.
View Article and Find Full Text PDFBackground and objectives Antimicrobial resistance (AMR) is a growing global threat, with carbapenemase-producing Enterobacterales (CPEs) representing a critical public health challenge. Rapid and accurate detection of CPEs is essential for controlling fatal bacterial AMR infections. This study evaluated the performance of MacConkey media supplemented with ertapenem (MacErt1 and MacErt2) for the detection of CPEs.
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- Extended-spectrum β-lactamase-producing (ESBL-) bacteria are a major public health issue due to their widespread resistance to multiple antibiotics, particularly among broiler chickens in Dakar, Senegal.
- A study found that 61.7% of broilers carried ESBL- in their cecum, with antibiotic tests revealing high resistance rates to various β-lactam antibiotics but full susceptibility to imipenem.
- The research indicates significant multidrug resistance and the presence of multiple ESBL genes, highlighting the risk of human transmission through the food supply and the need for better surveillance and intervention strategies.
Study Objectives: Rapid growth in childhood predisposes to obesity and cardiometabolic diseases in adulthood. While obstructive sleep apnea (OSA) is bidirectionally linked to obesity, its developmental origins are sparsely studied. We examined associations between postnatal growth and the risk of OSA in adulthood.
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- * In this study, two bacteriophages, vAbBal23 and vAbAbd25, were isolated from wastewater in Dakar, Senegal, and extensively characterized for their effectiveness against extremely drug-resistant strains of A. baumannii.
- * Both phages showed strong antibacterial properties across various pH levels and temperatures, with the ability to attack both active and biofilm forms of the bacteria, indicating their potential as safe therapeutic agents devoid of harmful genes.