Publications by authors named "C H Chue"
Background: Severe early graft dysfunction (EGD) is defined by mechanical circulatory support (MCS) <24 hours of heart transplantation (HT). We classified severe EGD based on timing of post-HT MCS: ''Immediate'' intra-operative vs ''Delayed'' post-operative MCS (after admission into intensive care unit (ICU) from operating theater). We hypothesized that (1) risk factors and clinical course differ between ''Immediate'' and ''Delayed'' MCS; and (2) diastolic perfusion pressure (DPP=diastolic blood pressure-central venous pressure) and Norepinephrine equivalents (NE=sum of vasopressor doses), as measures of vasoplegia are related to ''Delayed'' MCS.
View Article and Find Full Text PDFA fundamental problem in neuroscience is how neurons select for their many inputs. A common assumption is that a neuron's selectivity is largely explained by differences in excitatory synaptic input weightings. Here we describe another solution to this important problem.
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- An implantable left ventricular assist device (LVAD) is used in the UK mainly as a temporary solution for patients awaiting heart transplants or recovery.
- LVADs create a unique hemodynamic state, making standard measurements like blood pressure and pulse difficult to obtain, leading to challenges in patient assessment.
- To address these challenges, UK experts developed specific guidelines for managing emergencies in LVAD patients, aimed at healthcare providers in advanced heart failure centers, ensuring appropriate care during critical situations.
Article Synopsis
- There has been a significant rise in transthyretin amyloid cardiomyopathy (ATTR-CA) diagnoses, prompting the launch of the Midlands Amyloidosis Service to improve patient access to timely diagnoses and treatments.
- A descriptive study evaluated a hub-and-spoke model that connected patients from the Midlands region to a specialized multidisciplinary clinic, where ATTR-CA diagnoses were confirmed through validated criteria or imaging evidence.
- The study involved 173 patients referred between 2019 and 2021, with 68 diagnosed with ATTR-CA; the median time to diagnosis was 43 days, and the model helped reduce travel by saving patients an average of 187 miles.
Background: Correction of mitral regurgitation (MR) at the time of left ventricular assist device (LVAD) implantation remains controversial. There is conflicting evidence regarding the clinical impact of residual MR, and studies have not examined whether MR aetiology or right heart function impacts the likelihood of residual MR.
Methods: This is a retrospective single-centre study of 155 consecutive patients with LVAD implantation from January 2011 to March 2020.