TLE4 is a repressor of the oncogenic activity of TLX3 in T-cell acute lymphoblastic leukemia.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease originating from the malignant transformation of T-cell progenitors, caused by the accumulation of genetic aberrations. One-fifth of T-ALL patients are characterized by ectopic expression of the homeobox transcription factor TLX3. However, the role of TLX3 in T-ALL remains elusive, partly due to the lack of suitable study models.

Effects of ocean acidification and warming on apoptosis and immune response in the mussel Mytilus coruscus.

Ocean acidification and warming are significant stressors impacting marine ecosystems, exerting profound effects on the physiological ecology of marine organisms. We investigated the impact of ocean acidification and warming on the immune system of mussels, focusing on the regulatory mechanisms of intrinsic and extrinsic apoptosis. The study explored the effects on the immune response ability of mussels (Mytilus coruscus) after 14 and 21 days under combined conditions of different temperatures (20 °C and 30 °C) and pH (8.

First report of subsp. infecting southern shagbark hickory () in Georgia, USA.

Southern shagbark hickory (Carya carolinae-septentrionalis) is one of several deciduous trees in the family Juglandaceae and genus Carya that are native to North America. Southern shagbark hickory has a restricted distribution to the Southeast U.S.

Cardiac performance mirrors the passive thermal tolerance range in the oyster, Ostrea edulis.

Increasing frequencies of heatwaves threaten marine ectotherm species but not all alike. In exposed habitats, some species rely on a higher capacity for passive tolerance at higher temperatures, thereby extending time-dependent survival limits. Here we assess how the involvement of the cardiovascular system in extended tolerance at the margins of the thermal performance curve is dependent on warming rate.