Publications by authors named "C H Becker"
Objective: To study the timing of the effect of linzagolix, an oral GnRH antagonist, on significant reduction in heavy menstrual bleeding (HMB) in women with uterine fibroids.
Design: The study used pooled data from PRIMROSE1 and PRIMROSE2, two double-blind, similar placebo-controlled trials of linzagolix in US and Europe, respectively. Eligible participants were randomized equally across four treatment arms (linzagolix 100mg and 200mg, with and without concomitant hormonal add-back therapy [ABT] consisting of 1 mg estradiol and 0.
Article Synopsis
- Highly reactive metabolic intermediates can modify amino acid side chains, leading to non-enzymatic posttranslational modifications (nPTMs) of proteins, especially during high metabolic stress.
- Accumulation of nPTMs in long-lived proteins can affect protein structure and function, linking them to diseases like cataracts, diabetes, Alzheimer's, and Parkinson's.
- The review emphasizes the need for detailed research on nPTMs in neurodegenerative diseases, discussing their formation, impact on cellular processes, and advocating for advanced methods to study their effects on protein aggregation.
Objective: To aid the shortage of general practitioners (GPs) in Germany, since 2011 medical specialists from other fields may switch specialisation by undergoing a slim-lined training programme (lateral entry) into general practice (GP). Available published qualitative and quantitative data on lateral entrants (LEs) is scarce. Aim of the study was an explorative analysis of LEs in the competence centre for postgraduate medical education Baden-Wuerttemberg (KWBW).
View Article and Find Full Text PDFObjective: In Germany, the rotation into the general practitioner's practice (GPP) as part of postgraduate medical training in general practice traditionally takes place at the end of the training period. The aim of this study was to explore possible subsequent effects of beginning training in the GPP from the perspective of general practitioners (GPs) and GP trainees.
Methods: Nationwide, GPs and GP trainees were recruited who started specialization in GP in the GPP.
Background: Sleep-disordered breathing (SDB) is common among stroke survivors and is associated with worse functional, cognitive, and neurologic outcomes after stroke. Little is known about the association between changes in SDB and changes in these outcomes over time.
Methods: Ischemic stroke (IS) patients identified through the Brain Attack Surveillance in Corpus Christi project were offered SDB testing with a portable respiratory monitor (ApneaLink Plus) shortly after stroke, and at 3-, 6-, and 12-months post-stroke.