Publications by authors named "C H Beard"
Background/objectives: The biological basis for behavioral manifestations of Alzheimer's disease remains unclear. Emotional and behavioral alterations of Alzheimer's disease can result in substantial caregiver burden and lack effective management. This study expands upon previous work investigating behavioral alterations in mice with Alzheimer's disease and a potential treatment of increasing brain-derived neurotrophic factor (BDNF) using repetitive transcranial magnetic stimulation (rTMS).
View Article and Find Full Text PDFCurrent biomechanical models suggest that butterflies and moths use their proboscis as a drinking straw pulling nectar as a continuous liquid column. Our analyses revealed an alternative mode for fluid uptake: drinking bubble trains that help defeat drag. We combined X-ray phase-contrast imaging, optical video microscopy, micro-computed tomography, phylogenetic models of evolution and fluid mechanics models of bubble-train formation to understand the biomechanics of butterfly and moth feeding.
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- The study investigates how post-traumatic stress symptoms (PTSS) impact treatment outcomes like depression, anxiety, and overall functioning among patients in partial hospital programs (PHP).
- A total of 1,298 adults participated, with linear regression analyses showing that those with severe PTSS had poorer improvement in mental health compared to those without trauma history or less severe symptoms.
- The findings suggest that severe PTSS could predict treatment outcomes in acute psychiatric settings, highlighting the importance of trauma-informed care despite limitations in generalizability due to the study's design.
Article Synopsis
- Cardiac surgery with cardiopulmonary bypass (CPB) can cause lung injuries, and this study evaluated the use of low frequency ventilation (LFV) during such procedures in patients needing valve surgery.
- A total of 63 patients participated, with primary outcomes focused on lung inflammation markers and secondary outcomes on lung function and mobility post-surgery.
- The results indicated that LFV was safe and effective, leading to better preserved lung function and movement, suggesting its potential for broader application in future studies.
Recombinant adeno-associated virus (rAAV) has become a prominent vector for clinical use. Despite an increase in successful clinical outcomes, the amount of high-quality rAAVs required for clinical trials and eventual commercial demand is difficult to produce, especially for genetic diseases that are prevalent or require high doses. Many groups are focused on establishing production processes that can produce sufficient rAAV while maintaining potency and quality.
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