Publications by authors named "C Gwiazdon"
Investigations of ethanol's (EtOH's) complex response profile, including locomotor and other effects, are likely to lead to a more in-depth understanding of the constituents of alcohol addiction. Locomotor activity responses to acute and repeated EtOH (2 g/kg, ip) exposures were measured in BXD recombinant inbred (RI) mice and their C57BL/6J (B6) and DBA/2J (D2) progenitors. Both the acute response and the change in initial EtOH response with repeated treatments were strain-dependent.
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- The stimulant effects of addictive drugs may predict their potential for addiction, highlighting the importance of assessing stimulant sensitivity in individuals.
- Research showed that mice bred for high sensitivity (FAST) were more responsive to various alcohols and barbiturates than those bred for low sensitivity (SLOW).
- Surprisingly, both FAST and SLOW mice reacted similarly to substances like d-amphetamine and caffeine, suggesting that the stimulant effects of some drugs may share a common biological mechanism, especially among certain classes of substances.