Publications by authors named "C Guillemet"
Objective: Treatment of high-grade serous ovarian carcinomas relies on surgery and chemotherapy, potentially followed by bevacizumab and/or poly (ADP-ribose) polymerase inhibitors (PARPi). The modeled CA-125 ELIMination rate constant K (KELIM) is a pragmatic indicator of tumor primary chemosensitivity. Although it is well established that mutations are associated with platinum sensitivity, the relationship between status and KELIM score has yet to be elucidated.
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- A phase 3 trial was conducted to compare the effectiveness of doxorubicin alone versus the combination of doxorubicin and trabectedin in treating advanced leiomyosarcoma.
- The trial involved 150 patients and showed that those receiving the combination therapy had a longer median overall survival (33 months) compared to those receiving doxorubicin alone (24 months), with lower death rates in the combination group.
- While the combination treatment improved progression-free survival (12 months vs. 6 months), it also led to a higher incidence of adverse events and dose reductions compared to doxorubicin alone.
Background And Aims: Alveolar soft part sarcoma (ASPS) is an ultra-rare chemo-resistant sarcoma in children, occurring preferentially in young adults. We aimed to describe and compare its clinical presentation and behaviour in children and young adults to determine whether the same therapeutic strategy should be addressed for both populations.
Methods: National retrospective multicentre study of children (0-18 years) vs.
Oogenesis is a developmental process leading to the formation of an oocyte, a haploid gamete, which upon fertilisation and sperm entry allows the male and the female pronuclei to fuse and give rise to a zygote. In addition to forming a haploid gamete, oogenesis builds up a store of proteins, mRNAs, and organelles in the oocyte needed for the development of the future embryo. In several species, such as , the polarity axes determinants of the future embryo must be asymmetrically distributed prior to fertilisation.
View Article and Find Full Text PDFBackground: We investigated the impact of the implementation of a network of reference centers for sarcomas (NETSARC) on the care and survival of sarcoma patients in France since 2010.
Patients And Methods: NETSARC (netsarc.org) is a network of 26 reference sarcoma centers with specialized multidisciplinary tumor boards (MDTBs), funded by the French National Cancer Institute (INCa) since 2010.