Publications by authors named "C Guardian"
Developmental pattern of urinary epidermal growth factor in the premature infant and the influence of gender.
J Clin Endocrinol Metab
March 1991
Article Synopsis
- The study analyzed urinary epidermal growth factor/creatinine (EGF/Cr) levels in 159 preterm infants, revealing that female infants have significantly higher EGF/Cr levels earlier than males.
- Levels in female infants were comparable to term values starting at 30-32 weeks, while males reached similar levels starting at 32-34 weeks.
- A follow-up on 28 infants showed that EGF/Cr levels correlated with both corrected gestational and postnatal ages, with significant changes in patterns noted at 32 weeks gestational age and 4 weeks postnatally.
Effect of congenital renal disease and neonatal thyroid status on urinary human epidermal growth factor concentrations.
Acta Endocrinol (Copenh)
October 1989
Article Synopsis
- The study investigates how renal disease and thyroid conditions affect the excretion of epidermal growth factor (EGF) in infants, focusing on the perinatal period.
- Urine samples were collected from infants with congenital renal disease, hypothyroidism, and hyperthyroidism to compare their EGF and creatinine excretion levels against a healthy control group of 190 infants.
- Results show that EGF excretion tends to increase earlier in gestation compared to creatinine; however, it is reduced in cases of renal disease and hypothyroidism, while hyperthyroidism leads to greater EGF excretion.
Fetal (20-21 day gestation) and neonatal (less than 5-day-old) rat islets were isolated from the glucagon-rich (dorsal) and glucagon-poor (ventral) pancreatic regions. After 1 or 2 wk in culture, groups of islets from each region were transferred to culture dishes containing Krebs-Ringer bicarbonate buffer with low (2.4 mM) and high (16.
View Article and Find Full Text PDFFetal rat islet insulin deficiency following maternal administration of streptozotocin.
Proc Soc Exp Biol Med
November 1985
Pancreatic islets were isolated from the fetuses of normal rats and rats made diabetic by the iv administration of streptozotocin (STZ) on either Day 3 or 5 of pregnancy. Of the rats made diabetic on Day 3, one group also received insulin injections at the appearance of glucosuria. Maternal blood glucose on Day 20 of gestation was significantly different in the diabetic rats (405 +/- 27 mg/dl) from the normal (97 +/- 1 mg/dl) and insulin-treated diabetic rats (69 +/- 9 mg/dl).
View Article and Find Full Text PDFHomogeneous magnetic fields influence pancreatic islet function in vitro.
Biochem Biophys Res Commun
July 1984
Pancreatic islets were isolated from newborn rats and exposed to homogeneous magnetic fields for 48 hours. Under these conditions insulin release, measured at low (5.6 mM) and high (16.
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