Serum S-100B protein in severe head injury.

Objective: Despite the significant recent progress in cerebral monitoring, it is still difficult to quantify the extent of primary brain injury and ongoing secondary damage after head injury. The objective of our study was to investigate S-100B protein as a serum marker of brain damage after severe head injury.

Methods: Eighty-four patients with severe head injury (Glasgow Coma Scale score < or =8) were included in this prospective study.

Serum markers of brain damage and outcome prediction in patients after severe head injury.

The objective of the study was to investigate the validity of outcome prediction after severe head injury using serum levels of S-100B protein and neuron specific enolase. Eighty-two patients with severe head injury were included in this prospective study. Venous blood samples were taken after admission and every 24 h for a maximum of 10 consecutive days.

Correlation of computed tomography findings and serum brain damage markers following severe head injury.

The objective of our study was to investigate the association between the initial levels of serum S-100B protein and neuron specific enolase and the severity of radiologically visible brain damage and outcome after severe head injury. Admission computed tomography (CT) scans of forty-four patients with severe head injury were analysed. Initial levels of S-100B protein and neuron specific enolase were compared between the different outcome groups at 6 month, the different categories of the Marshall classification, the presence of traumatic subarachnoid haemorrhage, the type of haematoma and the volume of contusion.