Publications by authors named "C Grines"

Background: Mitral valve regurgitation (MR) is associated with worse outcomes in patients undergoing percutaneous coronary intervention (PCI). We sought to evaluate outcomes of Impella-supported high-risk PCI (HRPCI) patients according to MR severity.

Methods: Patients from the PROTECT III study undergoing Impella-supported HRPCI were stratified into 4 groups according to MR severity: No or trace MR, mild MR, moderate MR, and severe MR.

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Background: Patients with complex coronary artery disease, as defined by high SYNTAX scores, undergoing percutaneous coronary intervention (PCI) have poorer outcomes when compared with patients with lower SYNTAX I scores. This study aimed to assess if mechanical circulatory support using Impella mitigates the effect of the SYNTAX I score on outcomes after high-risk percutaneous coronary intervention (HRPCI).

Methods: Using data from the PROTECT III study, patients undergoing Impella-assisted HRPCI between March 2017 and March 2020 were divided into 3 cohorts based on SYNTAX I score-low (≤22), intermediate (23-32), and high (≥33).

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Article Synopsis
  • Anemia is common among patients with cardiovascular disease, particularly those undergoing high-risk percutaneous coronary intervention (HRPCI) with Impella support, and is linked to worse outcomes.
  • The study evaluated patients' hemoglobin levels to categorize them into no anemia, mild anemia, and moderate/severe anemia, revealing that anemic patients tended to be older and had more health issues.
  • Results showed that anemia significantly increased rates of major adverse cardiovascular events and major bleeding at 30 and 90 days, highlighting the need for focused strategies to manage anemia's impact on patient outcomes after HRPCI.
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