Publications by authors named "C Gregolin"
Aims: To identify the cardiac biogenic amine profile of obese rats and associate these compounds with parameters of cardiovascular disease.
Main Methods: Wistar rats (n = 20) were randomly distributed into two groups: control and obese. Obesity was induced by a high-sugar fat diet.
Introduction: High sucrose intake is linked to cardiovascular disease, a major global cause of mortality worldwide. Calcium mishandling and inflammation play crucial roles in cardiac disease pathophysiology.
Objective: Evaluate if sucrose-induced obesity is related to deterioration of myocardial function due to alterations in the calcium-handling proteins in association with proinflammatory cytokines.
Effects of carnosine supplementation on markers for the pathophysiological development of metabolic dysfunction-associated steatotic liver disease in a diet-induced model.
Núbia Alves Grandini Mariane Róvero Costa Cristina Schmitt Gregolin Juliana Silva Siqueira Taynara Aparecida Vieira
Mol Cell Endocrinol
March 2024
Article Synopsis
- A high-sugar and high-fat diet is linked to a liver condition called Metabolic dysfunction-associated steatotic liver disease (MASLD), which leads to increased fat accumulation in the liver.
- In a study with rats, carnosine (CAR) was administered to evaluate its effects on MASLD, comparing groups on normal diets and high-caloric diets.
- Results showed that CAR treatment reduced fat and cholesterol levels in the liver, improved metabolic markers, and could potentially be a therapeutic option for controlling MASLD.
Article Synopsis
- Researchers studied the effects of an early exercise program on cardiac dysfunction in rats with aortic stenosis, focusing on how exercise impacts heart structure and function post-surgery.
- The study involved different groups of rats, including a trained group, and used treadmill running for 16 weeks to assess improvements in heart health and metabolism.
- Results showed that early exercise significantly enhanced functional capacity and reduced heart remodeling and dysfunction, while also benefiting lipid metabolism and angiogenesis in the trained aortic stenosis rats.