Generating a Statistically Constrained Quaternary Model of a Buried Bedrock Valley Using FDEM.

An airborne electromagnetic (AEM) survey was conducted using the Resolve™ frequency-domain system over a buried bedrock valley near Elora, Ontario, Canada. A statistical bootstrapping approach was used to establish a relationship between the electrical resistivity from spatially interpolated one-dimensional AEM resistivity models and the lithostratigraphy of Quaternary sediments logged in continuously cored holes located within and adjacent to the buried bedrock valley. Three lithology types were classified using a bootstrapping approach: (i) clay, (ii) sandy to muddy diamicton with the presence of clasts, and (iii) sand/gravel.

Rapid, reference-free identification of bacterial pathogen transmission using optimized split -mer analysis.

Infections caused by multidrug-resistant organisms (MDROs) are difficult to treat and often life threatening and place a burden on the healthcare system. Minimizing the transmission of MDROs in hospitals is a global priority with genomics proving to be a powerful tool for identifying the transmission of MDROs. To optimize the utility of genomics for prospective infection control surveillance, results must be available in real time, reproducible and simple to communicate to clinicians.

Exposure to third hand e-cigarette vapour impairs cognitive function in young mice.

Indoor vaping can lead to third-hand vapour exposure, evidenced by the presence of nicotine and carcinogenic nitrosamines on indoor surfaces. Children are at high risk of such exposure. This study aimed to investigate the effects of third-hand vapour exposure on cognitive function in young mice.

Changes in isolation guidelines for CPE patients results in only mild reduction in required hospital beds.

Background: Carbapenemase-producing Enterobacterales (CPE) are an emerging public health concern globally as they are resistant to a broad spectrum of antibiotics. Colonisation with CPE typically requires patients to be managed under 'contact precautions', which creates additional physical bed demands in healthcare facilities.

Methods: This study examined the potential impact of revised isolation guidelines introduced in late 2023 in Victoria, Australia, that relaxed the requirement for indefinite isolation of CPE-colonised patients in contact precautions, based on admission of CPE-diagnosed cases prior to the guideline change.

Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.

Multidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients with liver disease, causes cross-resistance to daptomycin in VREfm.