Publications by authors named "C Gonzalez-Rubio"

Studies of phylogeographic patterns provide insight into the processes driving lineage divergence in a particular region. To identify the processes that caused phylogeographic breaks, it is necessary to use historical information and a set of appropriate molecular data to explain current patterns. To understand the influence of geological or ecological processes on the phylogeography of the only species of hummingbird endemic to the Baja California Peninsula, Hylocharis xantusii, mitochondrial DNA sequences of three concatenated genes (Cyt-b, COI and ND2; 2297bp in total) in 100 individuals were analyzed.

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Introduction: dengue is a viral disease with endemic behavior. At the beginning of the illness it is not possible to know which patients will have an unfavorable evolution and develop a severe form of dengue. However, some warning symptoms and signs may be present.

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Complement Factor I (CFI) is a regulator of the classical and alternative pathways. CFI has enzymatic activity and is able to cleave C3b and C4b. Homozygous Factor I deficiency is associated with infectious and/or autoimmune diseases.

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A subgroup of patients with the most severe form of the Hemolytic Uremic Syndrome (HUS) presents mutations in the complement regulatory protein factor H. The functional analyses of the factor H mutant proteins purified from some of these patients have shown a specific defect in the capacity to control complement activation on cellular surfaces. Here, we show that these factor H-related complement regulatory defects can be detected in the patients' serum with a simple hemolytic assay.

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Article Synopsis
  • Over 30 days, the amount of a molecule called CR1 on red blood cells decreases by about two-thirds, especially in certain diseases like SLE and AIDS.
  • When red blood cells are grown in a lab, they release tiny pieces called microvesicles that also lose CR1 and another molecule called DAF.
  • In patients with factor I deficiency, there is a higher loss of CR1 compared to normal cases, but no CR1 fragments were found on their red blood cells, suggesting a special problem with CR1 in this condition.
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