Publications by authors named "C Goicoechea"
People with chronic pain mitigate their suffering by the action of opioids. Adverse reactions aside, opioids are not exempt from potential complications like addiction and abuse, which have posed a global public health problem lately. Finding new therapeutic strategies to improve analgesia and to reduce opioid side effects has become a priority.
View Article and Find Full Text PDFThe peripheral inflammatory response is an attractive therapeutic target for pain treatment. Neutrophils are the first circulating inflammatory cells recruited to sites of injury, but their contribution to pain outcomes is unclear. We performed a systematic review and meta-analysis of original preclinical studies, which evaluated the effect of preemptive neutrophil depletion on pain outcomes (PROSPERO registration number: CRD42022364004).
View Article and Find Full Text PDFArticle Synopsis
- - The review aims to explore potential biomarkers in blood and cerebrospinal fluid for diagnosing and treating neuropathic pain, given the incomplete understanding of this condition.
- - A systematic search of six research databases led to analyzing 16 studies, revealing no significant differences in inflammatory biomarkers (CRP, IL-6, TNF-alpha) between patients with neuropathic pain and those without.
- - Results highlight the complexity of neuropathic pain, showing methodological strengths but limited by publication bias and variability in study findings, indicating the necessity for further research to identify reliable biomarkers.