Publications by authors named "C Glueer"
Background: Bisphosphonates are a main component in the therapy of osteoporosis and other bone resorptive diseases. Previous studies have shown a positive effect of systemically applied bisphosphonates on fracture healing. Nevertheless high doses are related to side effects like osteonecrosis of the jaw, nephrotoxis and gastrointestinal symptoms.
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- The study aimed to investigate the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) in older women, noting its changes over time and comparing it with other calcium metabolic disorders.
- A total of 2419 older women participated in a 6-year study, with 57 women (2.4%) identified with NHYPO, showing significantly lower bone turnover markers.
- Findings suggest that NHYPO is common in this population, tends to be non-persistent, and is associated with lower bone turnover, marking it as the first extensive population-based research on this condition in older women.
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- The study examines how different image voxel sizes affect finite element models used to predict bone strength in thoracolumbar vertebrae.
- Two scanning protocols created datasets with varying voxel sizes before and after autopsy, allowing the researchers to compare results.
- While voxel size didn't impact bone mineral density, significant differences were found in the apparent modulus and yield strength between the different voxel sizes, suggesting voxel size should be considered in clinical finite element modeling.
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- Bisphosphonates, like alendronate, are commonly used to treat osteoporosis by reducing fracture risk through decreased bone resorption, but this lower turnover might negatively affect bone quality.
- A study compared the structural and mechanical characteristics of cancellous bone in osteoporotic patients who received different durations of alendronate treatment versus untreated controls.
- Findings showed that while treated patients had improved mineralization and less eroded bone surface, their microdamage and overall mechanical properties were similar to untreated controls, indicating that alendronate treatment does not harm bone strength over time.
In order to interpret bone turnover markers (BTMs), we need to establish healthy reference intervals. It is difficult to establish reference intervals for older women because they commonly suffer from diseases or take medications that affect bone turnover. The aims of this study were: (1) to identify diseases and drugs that have a substantial effect on BTMs; (2) to establish reference intervals for premenopausal and postmenopausal women; and (3) to examine the effects of other factors on BTMs in healthy postmenopausal women.
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