Publications by authors named "C Giuffrida"
Neurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system.
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- Cardiovascular diseases are the leading cause of death for women, even with 30 years of medical advances.
- Women often get heart diseases later in life than men and show unusual symptoms that are hard to recognize.
- The paper discusses how gender affects heart health and looks into the research on diagnosis and treatment for women.
Article Synopsis
- - Chronic inflammation in patients with inflammatory rheumatic diseases (IRD) leads to increased cardiovascular (CV) risks, contributing to higher mortality rates compared to the general population due to premature atherosclerosis.
- - Effective CV risk assessment and early diagnosis of silent cardiovascular disease (CVD) are critical for improving long-term outcomes, yet standard care often falls short in these areas.
- - Arterial stiffness, measured through methods like pulse wave velocity (PWV), serves as a valuable biomarker for predicting cardiovascular events and stratifying risk in patients with vasculitis, highlighting the need for better monitoring and management strategies.
miR profile could be associated to CV risk, and also to prognosis/outcome in response to therapeutic approach. We aimed to evaluate if anti-hypertensive drugs enalapril, losartan or olmesartan have effects on monocyte miR profile in essential hypertensives without target organ involvement. For this purpose, 82 hypertensives and 49 controls were included; we evaluated SBP/DBP, lipid profile, glucose, CRP, fibrinogen, arterial stiffness indices (PWV; AIx), and cIMT at baseline (T0) and after 24 weeks of treatment (T1).
View Article and Find Full Text PDFAssociation between preoperative evaluation with lung ultrasound and outcome in frail elderly patients undergoing orthopedic surgery for hip fractures: study protocol for an Italian multicenter observational prospective study (LUSHIP).
Ultrasound J
June 2021
Article Synopsis
- Hip fractures are common in elderly, frail patients and carry a high risk of complications after surgery, which traditional risk assessments often underestimate.
- This study, LUSHIP, aims to determine if preoperative lung ultrasound (LU) can better predict postoperative issues in patients over 65 undergoing hip fracture surgery, using a scoring system based on lung aeration patterns.
- The study will involve 877 patients across 12 centers in Italy and aims to assess the relationship between lung health and postoperative cardiac or pulmonary complications with a focus on improving surgical outcomes.