Publications by authors named "C Giordanino"
Background & Aims: limited evidence is available to guide hepatologists regarding endoscopic surveillance of oesophageal varices (EV) in Hepatitis C Virus (HCV)-positive cirrhotic patients achieving a sustained virologic response. To address these issues, we conducted a long-term prospective study on 427 HCV-positive cirrhotic patients successfully treated by Direct Antiviral Agents (DAAs).
Methods: Patients were divided into two groups according to their baseline Baveno VI status: Group 1 (92, 21.
Background And Aims: Clearance of hepatitis C virus (HCV) is associated with improved glycometabolic control in patients with diabetes mellitus (DM) but whether this effect is maintained over the long term with a reduction in liver-related events (LRE) is still debated. To address these issues, we conducted a long-term prospective study on diabetic and non-diabetic patients with chronic hepatitis C cured by direct antiviral agents (DAAs).
Methods: Among 893 recruited patients, 15.
Background: Obesity, type 2 diabetes (T2D), dyslipidemia, arterial hypertension as well as hepatic steatosis (HS) are common conditions that can affect clinical outcomes of patients with chronic hepatitis C (CHC) who achieved sustained virologic response (SVR). The aim of this study was to assess the impact of metabolic cofactors on the occurrence of clinical events during follow-up (FU) in a group of CHC long-term responders (LTRs) to interferon- (IFN) based therapy.
Methods: A total of 5172 medical records of CHC patients enrolled from 1990 to 2011 were examined; 1034 of 5172 (20%) patients were treated with IFN-based therapy and 382 of 1034 (37%) of them achieved SVR.
The most commonly used regimens fail to eradicate () infection in 5⁻10% of patients. Those not cured with treatments based on amoxicillin, clarithromycin, nitroimidazoles, fluoroquinolones, bismuth or tetracycline have no other conventional options thereafter. In this prospective long-term monocentric study, patients who failed to eradicate following treatment with all conventional antibiotics were included.
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- The study focused on how treating hepatitis C (HCV) with direct-acting antivirals (DAAs) affects blood sugar levels in type 2 diabetes patients.
- It found that HCV patients who achieved Sustained Virologic Response (SVR) experienced significant improvements in fasting glucose and glycated hemoglobin levels compared to those who didn’t.
- Despite some weight gain in patients who achieved SVR, about 20.7% were able to reduce or stop their diabetes medications, indicating potential benefits from the HCV treatment.