Systematic review on the cost of seasonal malaria chemoprevention (SMC).

Background: Implemented in 17 countries to date, seasonal malaria chemoprevention (SMC) is a recommended strategy to prevent childhood malaria in areas with seasonal transmission of P. falciparum through monthly administration of antimalarial medicines. Understanding the costs and resource requirements of SMC delivery is necessary for effective planning and resource allocation.

Evidence for sodium valproate toxicity in mitochondrial diseases: a systematic analysis.

Background: We aimed to determine whether sodium valproate (VPA) should be contraindicated in all mitochondrial diseases, due to known VPA-induced severe hepatotoxicity in some mitochondrial diseases.

Methods: We systematically reviewed the published literature for mitochondrial DNA (mtDNA) and common nuclear genotypes of mitochondrial diseases using PubMed, Ovid Embase, Ovid Medline and MitoPhen databases. We extracted patient-level data from peer-reviewed articles, published until July 2022, using the Human Phenotype Ontology to manually code clinical presentations for 156 patients with genetic diagnoses from 90 publications.

Real-world data on siponimod-related lymphopenia among people with secondary progressive multiple sclerosis.

Background: Siponimod-related lymphopenia in real-world clinical practice has implications for dose adjustment and infection risk.

Objective: To characterise siponimod-related lymphopenia in people with secondary progressive multiple sclerosis (pwSPMS).

Methods: This is a retrospective cohort of 188 pwSPMS.

An assessment of primary health care costs and resource requirements in Kaduna and Kano, Nigeria.

Introduction: The availability of quality primary health care (PHC) services in Nigeria is limited. The PHC system faces significant challenges and the improvement and expansion of PHC services is constrained by low government spending on health, especially on PHC. Out-of-pocket (OOP) expenditures dominate health spending in Nigeria and the reliance on OOP payments leads to financial burdens on the poorest and most vulnerable populations.