Publications by authors named "C Giard"
Background: Paired survival data are often used in clinical research to assess the prognostic effect of an exposure. Matching generates correlated censored data expecting that the paired subjects just differ from the exposure. Creating pairs when the exposure is an event occurring over time could be tricky.
View Article and Find Full Text PDFBackground: Ipilimumab is a monoclonal antibody targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) that allows increased survival and, occasionally, complete remission, in the treatment of metastatic melanoma. The most frequent adverse effects are attributed to dysimmunity. We report the case of a female patient who developed orbital myositis during treatment with ipilimumab.
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- Hereditary C1-inhibitor deficiency is linked to bradykinin-mediated angio-oedema, while acquired angio-oedema has been associated with estrogen contraceptives.
- The study aimed to establish that estrogen-related angio-oedema is mediated by bradykinin and to assess the prevalence of urticaria in these patients.
- Results indicated that discontinuing estrogen led to normalization of plasma components and significant improvement in symptoms, suggesting that recurrent urticaria could occur alongside bradykinin-mediated angio-oedema.
From 1960 to 1989, 154 cases of recurrent breast cancer after conservative radiosurgery were treated at the Curie Institute. Relapse was discovered at clinical examination in 88% of the cases and mammography was only useful in 45%. In 18 cases (12%) an unpalpable tumour was discovered at mammography, especially for intragalactophoric tumors.
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