Publications by authors named "C Giannone"
Article Synopsis
- - Polymeric IgM, an important immunoglobulin, has a strong ability to bind antigens and complements, primarily produced as hexamers or pentamers, with the latter containing a protein called the J-chain for enhanced transportation across cell layers.
- - The study reveals that the J-chain competes with the sixth subunit during IgM assembly and exists in an unstructured form before stabilizing pentamer formation through interactions with newly formed structures.
- - The process is regulated by a quality control factor known as ERp44, which ensures that only properly assembled IgM is secreted, thereby ensuring effective immune responses.
In the dairy cattle sector, the evaluation of the effects induced by heat stress is still one of the most impactful and investigated aspects as it is strongly connected to both sustainability of the production and animal welfare. On the other hand, more recently, the possibility of collecting a large dataset made available by the increasing technology diffusion is paving the way for the application of advanced numerical techniques based on machine learning or big data approaches. In this scenario, driven by rapid change, there could be the risk of dispersing the relevant information represented by the physiological animal component, which should maintain the central role in the development of numerical models and tools.
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- * No significant differences were found in meat quality traits like drip loss and color; however, the GP diet improved the fatty acid profile, increasing beneficial acids like stearic, vaccenic, and rumenic acids.
- * The GP supplementation also enhanced the meat's oxidative stability, reducing oxidation indicators and potentially improving the meat's shelf life and health benefits.
Antibodies of the immunoglobulin M (IgM) class represent the frontline of humoral immune responses. They are secreted as planar polymers in which flanking µ L "monomeric" subunits are linked by two disulfide bonds, one formed by the penultimate cysteine (C575) in the tailpiece of secretory µ chains (µ tp) and the second by C414 in the Cµ3. The latter bond is not present in membrane IgM.
View Article and Find Full Text PDFObjective: Thrombosis represents one of the most feared complications of the COronaVIrus Disease-2019 (COVID-19). Although pulmonary embolism and deep venous thrombosis are the most described complications, some investigations reported thrombotic localization also in the splanchnic venous district.
Methods: We describe the case of a patient with SARS-CoV-2 infection presenting with abdominal pain and diagnosed with portal vein thrombosis.