Publications by authors named "C Giaccone"
Article Synopsis
- The study investigated the impact of switching to a less neurotoxic antiretroviral therapy (ARV) on neurocognitive performance in people living with HIV who have cognitive impairments.
- Participants were randomly assigned to either continue their current treatment or switch to a less harmful ARV regimen (MARAND-X) for 24 weeks, with results measured using various cognitive tests and electroencephalography.
- While the overall neurocognitive scores improved modestly, significant improvements were only seen in specific memory functions for those in the MARAND-X group with better CNS penetration, indicating that the effectiveness of ARVs in the central nervous system may influence cognitive health.
The prevalence of neurocognitive impairment in people living with HIV is estimated between 30 and 50%. The pathogenesis of HIV-associated neurocognitive disorders is complex and multifactorial. Aim of the study was to measure the change in CSF biomarkers, Fibroscan and IMT measurements in PLWH with HAND randomized to a less neurotoxic regimen, or continuing their treatment.
View Article and Find Full Text PDFObjective: To evaluate the long-term effects of laparoscopic Roux-en-Y Gastric Bypass (LRYGB) on gastroesophageal function.
Background: LRYGB is considered the weight loss procedure of choice for obese patients with gastroesophageal reflux disease (GERD). However, long-term instrumental evaluations of GERD after LRYGB are not available.
Objective: To evaluate the effect of laparoscopic sleeve gastrectomy (LSG) on gastroesophageal reflux disease (GERD) in morbidly obese patients.
Background: Symptomatic GERD is considered by many a contraindication to LSG. However, studies evaluating the relationship between LSG and GERD by 24-hour pH monitoring are lacking.
Objective: Chronic cerebrospinal venous insufficiency (CCSVI) has been extremely variable, associated with multiple sclerosis in colour-Doppler sonographic studies. We aimed to evaluate inter-rater agreement in a colour-Doppler sonography venous examination.
Design: Inter-rater agreement study.