Publications by authors named "C Geronimo-Olvera"
X-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within intron 32 of TATA-binding protein associated factor 1 (TAF1) that causes an alteration of TAF1 splicing, partial intron retention, and decreased transcription. Although TAF1 is expressed in all organs, medium spiny neurons (MSNs) within the striatum are one of the cell types most affected in XDP.
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- Following peripheral nerve injury, Schwann cells must reprogram to support axonal growth, which is hindered by aging and chronic denervation.
- Reduced c-Jun expression in Schwann cells is linked to regeneration failure, and the study shows that these cells can enter a senescent state, negatively impacting nerve repair.
- Targeting and eliminating senescent Schwann cells using specific drugs demonstrated improved nerve regeneration and recovery, suggesting potential new treatments for enhancing recovery after nerve injuries.
Article Synopsis
- Ischemic stroke is a major health problem that can cause disabilities, and there's no easy way to treat the brain injuries it causes.
- Researchers are looking into the ketogenic diet and a special type of ketone called D-BHB as possible treatments to help reduce brain damage from strokes.
- D-BHB has been shown to help protect brain cells by boosting a process that keeps the cell clean and healthy, while a similar ketone called L-BHB does not work as well.
Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment promotes cellular senescence. CRM1 (exportin-1/XPO1) exports hundreds of nuclear proteins into the cytoplasm, including the transcription factors TFEB (the main inducer of autophagy and lysosomal biogenesis genes) and STAT3, another autophagy modulator.
View Article and Find Full Text PDFAltered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the unfolded protein response (UPR), which can act as a homeostatic response or lead to cell death. However, the factors involved in turning and adaptive response into a cell death mechanism are still not well understood.
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