Publications by authors named "C Gerner"
Article Synopsis
- Lipid-containing vacuoles in microglia have been associated with neurodegenerative disorders for over a century, and recent studies show altered lipid metabolism in these conditions.
- Research focused on how lipid-enriched nanoparticles affect microglia, revealing that these nanoparticles lead to vacuolization and the formation of Gitterzellen, a distinct microglia phenotype seen in Alzheimer's disease.
- The study suggests that lipid-nanoparticles trigger this process through specific pathways, providing a valuable in vitro model to investigate the long-term effects of neurodegeneration.
Article Synopsis
- Biological sex is crucial for archeological and forensic studies, but current methods lack standardization for fast and accurate identification.
- A new mass spectrometry-based workflow using human dental enamel allows for efficient sex determination, processing up to 200 samples per day with high accuracy.
- This method has been validated on various teeth and successfully applied to archeological materials, enhancing the ability to study large populations rather than just individual specimens.
RiboScreen Technology Delivers a Ribosomal Target and a Small-Molecule Ligand for Ribosome Editing to Boost the Production Levels of Tropoelastin, the Monomeric Unit of Elastin.
Bjoern Wimmer Jan Schernthaner Genevieve Edobor Andreas Friedrich Katharina Poeltner Christopher Gerner
Int J Mol Sci
August 2024
Article Synopsis
- Elastin is crucial for skin elasticity and decreases with age, making it a target for anti-aging products.
- RiboScreen technology was used to find ribosomal proteins that enhance the production of tropoelastin, identifying ribosomal protein L40 (eL40) as a key regulator.
- A small molecule that activates eL40 was discovered, leading to increased levels of tropoelastin in cells, suggesting potential applications in skincare and cardiovascular health.
Article Synopsis
- Mass spectrometry-based omics technologies are utilized in drug effect studies, highlighting how fold change and experimental variation impact the identification of molecular events in biological pathways.
- Memory effects from prior subculture significantly influence the variation observed in perturbation profiles of colon carcinoma cell lines, with these effects differing based on cell growth states.
- Controlling subculture homogeneity enhanced the identification of causal relationships in perturbation networks, revealing new insights into arsenic trioxide's mode of action and potential treatment combinations for overcoming resistance mechanisms.